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Molecular Profile | SMARCB1 loss |
Therapy | Tazemetostat |
Indication/Tumor Type | nasal cavity carcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
SMARCB1 loss | nasal cavity carcinoma | predicted - sensitive | Tazemetostat | Case Reports/Case Series | Actionable | In a clinical study, Tazverik (tazemetostat) resulted in a clinical benefit in two patients with loss of SMARCB1, including one patient with sinonasal carcinoma and the other patient with sinonasal undifferentiated carcinoma, with stable disease lasting 13 and 8 months, respectively (PMID: 35820243). | 35820243 |
PubMed Id | Reference Title | Details |
---|---|---|
(35820243) | Tazemetostat for the treatment of INI-1-deficient sinonasal tumor. | Full reference... |