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Molecular Profile | FLT3 exon 14 ins |
Therapy | Saridegib + Sorafenib |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins | acute myeloid leukemia | sensitive | Saridegib + Sorafenib | Preclinical - Cell culture | Actionable | In a preclinical study, treatment with the combination of Nexavar (sorafenib) and Saridegib (IPI-926) resulted in significantly decreased cell proliferation compared to Nexavar (sorafenib) alone in two acute myeloid leukemia cell lines harboring FLT3-ITD mutations in culture (PMID: 26062848). | 26062848 |
PubMed Id | Reference Title | Details |
---|---|---|
(26062848) | Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. | Full reference... |