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Molecular Profile FLT3 exon 14 ins
Therapy Sonidegib + Sorafenib
Indication/Tumor Type acute myeloid leukemia
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins acute myeloid leukemia sensitive Sonidegib + Sorafenib Preclinical - Cell culture Actionable In a preclinical study, treatment with the combination of Nexavar (sorafenib) and Odomzo (sonidegib) resulted in significantly decreased cell proliferation compared to Nexavar (sorafenib) alone in an acute myeloid leukemia cell line harboring a FLT3-ITD mutation in culture (PMID: 26062848). 26062848
PubMed Id Reference Title Details
(26062848) Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. Full reference...