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Molecular Profile | FLT3 exon 14 ins |
Therapy | Sonidegib + Sorafenib |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins | acute myeloid leukemia | sensitive | Sonidegib + Sorafenib | Preclinical - Cell culture | Actionable | In a preclinical study, treatment with the combination of Nexavar (sorafenib) and Odomzo (sonidegib) resulted in significantly decreased cell proliferation compared to Nexavar (sorafenib) alone in an acute myeloid leukemia cell line harboring a FLT3-ITD mutation in culture (PMID: 26062848). | 26062848 |
PubMed Id | Reference Title | Details |
---|---|---|
(26062848) | Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. | Full reference... |