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Molecular Profile | FGFR3 dec exp FGFR3 wild-type HRAS G12V |
Therapy | Fexagratinib |
Indication/Tumor Type | transitional cell carcinoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR3 dec exp FGFR3 wild-type HRAS G12V | transitional cell carcinoma | resistant | Fexagratinib | Preclinical | Actionable | In a preclinical study, urothelial cancer cells with low expression of wild-type FGFR3 that harbored HRAS G12V demonstrated resistance to AZD4547 in culture (PMID: 22869148). | 22869148 |
PubMed Id | Reference Title | Details |
---|---|---|
(22869148) | Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance. | Full reference... |