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| Molecular Profile | POLE P286R |
| Therapy | Nivolumab |
| Indication/Tumor Type | endometrial cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| POLE P286R | endometrial cancer | predicted - sensitive | Nivolumab | Case Reports/Case Series | Actionable | In a Phase II trial, Opdivo (nivolumab) resulted in stable disease in an endometrial cancer patient harboring POLE P286R, along with high tumor mutational burden (PMID: 35398880; NCT03012581). | 35398880 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (35398880) | PD-1 Blockade in Solid Tumors with Defects in Polymerase Epsilon. | Full reference... |