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Molecular Profile | BRAF V600E |
Therapy | Cetuximab + Encorafenib + Ulixertinib |
Indication/Tumor Type | colorectal cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | colorectal cancer | predicted - sensitive | Cetuximab + Encorafenib + Ulixertinib | Case Reports/Case Series | Actionable | In an expanded access program (ULI-EAP-100), Ulixertinib (BVD-523), Braftovi (encorafenib), and Erbitux (cetuximab) combination therapy resulted in a complete response in a patient with colorectal cancer harboring BRAF V600E (J Clin Oncol 40, no. 16_suppl (June 01, 2022) e15101; NCT04566393). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Updated clinical outcomes from ULI-EAP-100, an intermediate expanded access program for ulixertinib (BVD-523). | Full reference... |