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| Molecular Profile | FGFR3 K652E |
| Therapy | PD173074 |
| Indication/Tumor Type | urinary bladder cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR3 K652E | urinary bladder cancer | resistant | PD173074 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, bladder cancer cells harboring FGFR3 K652E were resistant to PD173074 in culture and in cell line xenograft models (PMID: 23558953). | 23558953 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23558953) | Identification of targetable FGFR gene fusions in diverse cancers. | Full reference... |