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Molecular Profile | PIK3CA P539R PIK3CA H1047R |
Therapy | PF-04691502 |
Indication/Tumor Type | breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA P539R PIK3CA H1047R | breast cancer | sensitive | PF-04691502 | Preclinical - Cell culture | Actionable | In a preclinical study, PF-04691502 inhibited Akt phosphorylation and proliferation of breast cancer cells harboring both PIK3CA P539R and H1047R in culture (PMID: 21750219). | 21750219 |
PubMed Id | Reference Title | Details |
---|---|---|
(21750219) | PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. | Full reference... |