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| Molecular Profile | FANCA Q1307Sfs*6 |
| Therapy | Cisplatin + Olaparib |
| Indication/Tumor Type | hepatocellular carcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FANCA Q1307Sfs*6 | hepatocellular carcinoma | predicted - sensitive | Cisplatin + Olaparib | Case Reports/Case Series | Actionable | In a clinical case study, Lynparza (olaparib) and Platinol (cisplatin) combination treatment resulted in decreased tumor marker level within 1 month and disease stabilization with a progression-free survival of 12 months in a patient with hepatocellular carcinoma harboring FANCA Q1307Sfs*6 (PMID: 36181052). | 36181052 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36181052) | Durable response to olaparib combined low-dose cisplatin in advanced hepatocellular carcinoma with FANCA mutation: A case report. | Full reference... |