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| Molecular Profile | PTEN Y336* |
| Therapy | Talazoparib |
| Indication/Tumor Type | breast cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN Y336* | breast cancer | sensitive | Talazoparib | Preclinical - Cell culture | Actionable | In a preclinical study, breast cancer cells expressing PTEN Y336* demonstrated increased sensitivity to Talzenna (talazoparib) compared to cells expressing wild-type Pten in culture (PMID: 25946202}. | 25946202 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25946202) | Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure. | Full reference... |