Profile Response Detail

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Molecular Profile CD274 positive
Therapy Atezolizumab
Indication/Tumor Type uterine cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 positive uterine cancer predicted - sensitive Atezolizumab Case Reports/Case Series Actionable In a Phase I trial, Tecentriq (atezolizumab) treatment resulted in an objective response rate (ORR) of 13.3% (2/15, 2 partial responses) and a median progression-free survival of 1.4 months in patients with advanced or recurrent uterine cancer, ORR was 40% (2/5) in patients with tumor CD274 (PD-L1) expression of 5% or higher and 0% (0/10) in patients with tumor CD274 (PD-L1) expression below 5% (PMID: 31204078; NCT01375842). 31204078
PubMed Id Reference Title Details
(31204078) Safety, clinical activity and biomarker assessments of atezolizumab from a Phase I study in advanced/recurrent ovarian and uterine cancers. Full reference...