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| Molecular Profile | NTRK1 G667C |
| Therapy | JND4135 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NTRK1 G667C | Advanced Solid Tumor | predicted - sensitive | JND4135 | Preclinical - Biochemical | Actionable | In a preclinical study, JND4135 inhibited kinase activity of NTRK1 G667C in an in vitro assay (PMID: 36235036). | 36235036 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36235036) | JND4135, a New Type II TRK Inhibitor, Overcomes TRK xDFG and Other Mutation Resistance In Vitro and In Vivo. | Full reference... |