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Molecular Profile | PIK3CA E545K |
Therapy | Sirolimus |
Indication/Tumor Type | breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA E545K | breast cancer | sensitive | Sirolimus | Preclinical - Cell culture | Actionable | In a preclinical study, a breast cancer cell line harboring PIK3CA E545K demonstrated hypersensitivity to Rapamune (sirolimus)-induced growth inhibition in culture (PMID: 24631838). | 24631838 |
PubMed Id | Reference Title | Details |
---|---|---|
(24631838) | A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. | Full reference... |