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Molecular Profile | FGFR2 S267_D273dup |
Therapy | Infigratinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR2 S267_D273dup | Advanced Solid Tumor | sensitive | Infigratinib | Preclinical | Actionable | In a preclinical study, Truseltiq (infigratinib) prevented oncogenic transformation of cells expressing FGFR2 S267_D273dup (PMID: 26048680). | 26048680 |
PubMed Id | Reference Title | Details |
---|---|---|
(26048680) | Identification of Oncogenic and Drug-Sensitizing Mutations in the Extracellular Domain of FGFR2. | Full reference... |