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| Molecular Profile | FLT3 exon 14 ins FLT3 D839G |
| Therapy | Lestaurtinib |
| Indication/Tumor Type | hematologic cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins FLT3 D839G | hematologic cancer | sensitive | Lestaurtinib | Preclinical - Cell culture | Actionable | In a preclinical study, Lestaurtinib (CEP-701) inhibited proliferation of transformed cells expressing FLT3-ITD and FLT3 D839G in culture (PMID: 34768286). | 34768286 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34768286) | Momelotinib is a highly potent inhibitor of FLT3-mutant AML. | Full reference... |