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| Molecular Profile | FLT3 exon 14 ins FLT3 D835V |
| Therapy | Sorafenib |
| Indication/Tumor Type | hematologic cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins FLT3 D835V | hematologic cancer | resistant | Sorafenib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing FLT3-ITD and FLT3 D835V demonstrated resistance to Nexavar (sorafenib) in culture (PMID: 34768286). | 34768286 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34768286) | Momelotinib is a highly potent inhibitor of FLT3-mutant AML. | Full reference... |