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Molecular Profile | FLT3 exon 14 ins FLT3 D835Y |
Therapy | Pacritinib |
Indication/Tumor Type | hematologic cancer |
Response Type | conflicting |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins FLT3 D835Y | hematologic cancer | conflicting | Pacritinib | Preclinical - Cell culture | Actionable | In a preclinical study, Vonjo (pacritinib) inhibited phosphorylation of Flt3 and Stat5 and viability in a transformed cell line expressing a FLT3-ITD mutation and FLT3 D835Y in culture (PMID: 31102119). | 31102119 |
FLT3 exon 14 ins FLT3 D835Y | hematologic cancer | conflicting | Pacritinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing FLT3-ITD and FLT3 D835Y demonstrated resistance to Vonjo (pacritinib) in culture (PMID: 34768286). | 34768286 |
PubMed Id | Reference Title | Details |
---|---|---|
(34768286) | Momelotinib is a highly potent inhibitor of FLT3-mutant AML. | Full reference... |
(31102119) | Preclinical activity and a pilot phase I study of pacritinib, an oral JAK2/FLT3 inhibitor, and chemotherapy in FLT3-ITD-positive AML. | Full reference... |