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| Molecular Profile | FGFR3 S249C |
| Therapy | TYRA-300 |
| Indication/Tumor Type | urinary bladder cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR3 S249C | urinary bladder cancer | predicted - sensitive | TYRA-300 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, TYRA-300 induced tumor regression a cell line xenograft model of bladder cancer harboring FGFR3 S249C (Annals of Oncology 33 (2022): S751). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| 462P TYRA-300: FGFR3 selective and gatekeeper agnostic | Full reference... |