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Molecular Profile | EML4 - ALK ALK L1196M |
Therapy | Brigatinib |
Indication/Tumor Type | large cell neuroendocrine carcinoma |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
EML4 - ALK ALK L1196M | large cell neuroendocrine carcinoma | no benefit | Brigatinib | Case Reports/Case Series | Actionable | In a clinical case study, a heavily pretreated patient with metastatic large cell neuroendocrine lung carcinoma harboring EML4-ALK (e20:e20) and ALK L1196M did respond to Alunbrig (brigatinib) treatment (PMID: 36207130). | 36207130 |
PubMed Id | Reference Title | Details |
---|---|---|
(36207130) | Lorlatinib and compound mutations in ALK+ large-cell neuroendocrine lung carcinoma: a case report. | Full reference... |