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Molecular Profile ALK rearrange ALK T1151R
Therapy Brigatinib
Indication/Tumor Type lung adenocarcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK rearrange ALK T1151R lung adenocarcinoma predicted - sensitive Brigatinib Case Reports/Case Series Actionable In a clinical case study, Alunbrig (brigatinib) treatment resulted in clinical improvement and a major response in tumor volume and metabolic activity in a patient with metastatic lung adenocarcinoma harboring an ALK rearrangement and ALK T1151R until disease progression 3 months later (PMID: 31027750). 31027750
PubMed Id Reference Title Details
(31027750) Ceritinib ALK T1151R Resistance Mutation in Lung Cancer With Initial Response to Brigatinib. Full reference...