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Molecular Profile | NRAS G13R PIK3CA E545K |
Therapy | Binimetinib + Ribociclib |
Indication/Tumor Type | melanoma |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS G13R PIK3CA E545K | melanoma | predicted - resistant | Binimetinib + Ribociclib | Case Reports/Case Series | Actionable | In a Phase Ib/II trial, a patient with melanoma harboring NRAS G13R experienced disease progression on combination treatment with Mektovi (binimetinib) and Kisqali (ribociclib), likely due to the acquisition of PIK3CA E545K (PMID: 29496665; NCT01781572). | 29496665 |
PubMed Id | Reference Title | Details |
---|---|---|
(29496665) | A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling. | Full reference... |