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Molecular Profile | ALK F1174V |
Therapy | Repotrectinib |
Indication/Tumor Type | neuroblastoma |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ALK F1174V | neuroblastoma | predicted - resistant | Repotrectinib | Preclinical - Pdx | Actionable | In a preclinical study, a neuroblastoma patient-derived xenograft (PDX) model harboring ALK F1174V was resistant to treatment with Augtyro (repotrectinib) (PMID: 34482287). | 34482287 |
PubMed Id | Reference Title | Details |
---|---|---|
(34482287) | Translational Strategies for Repotrectinib in Neuroblastoma. | Full reference... |