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| Molecular Profile | FGFR2 L776Rfs*6 |
| Therapy | Fexagratinib |
| Indication/Tumor Type | breast cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR2 L776Rfs*6 | breast cancer | predicted - sensitive | Fexagratinib | Preclinical - Cell culture | Actionable | In a preclinical study, Fexagratinib (AZD4547) inhibited growth of mouse mammary epithelial cells expressing FGFR2 L681Rfs*6 (corresponding to L776Rfs*6 in human) in culture (PMID: 35948633). | 35948633 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (35948633) | Truncated FGFR2 is a clinically actionable oncogene in multiple cancers. | Full reference... |