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Molecular Profile | BRAF T599dup |
Therapy | Cetuximab |
Indication/Tumor Type | colorectal cancer |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF T599dup | colorectal cancer | resistant | Cetuximab | Preclinical - Pdx | Actionable | In preclinical study, a colorectal cancer patient-derived xenograft (PDX) model harboring BRAF T599dup was resistant to Erbitux (cetuximab) treatment (PMID: 31515458). | 31515458 |
PubMed Id | Reference Title | Details |
---|---|---|
(31515458) | Response to Anti-EGFR Therapy in Patients with BRAF non-V600-Mutant Metastatic Colorectal Cancer. | Full reference... |