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Molecular Profile | IDH1 R132H |
Therapy | IDH1 R132H peptide vaccine |
Indication/Tumor Type | malignant astrocytoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
IDH1 R132H | malignant astrocytoma | predicted - sensitive | IDH1 R132H peptide vaccine | Phase I | Actionable | In a Phase I trial (NOA-16), treatment with IDH1 R132H peptide vaccine demonstrated safety in patients with malignant astrocytoma harboring IDH1 R132H and led to stable disease in 87.5% (28/32) of patients (J Clin Oncol 36, no. 15_suppl (May 20, 2018) 2001; NCT02454634). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
A mutation-specific peptide vaccine targeting IDH1R132H in patients with newly diagnosed malignant astrocytomas: A first-in-man multicenter phase I clinical trial of the German Neurooncology Working Group (NOA-16) | Full reference... |