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Molecular Profile | KMT2A rearrange FLT3 exon 14 ins |
Therapy | Revumenib |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KMT2A rearrange FLT3 exon 14 ins | acute myeloid leukemia | sensitive | Revumenib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Revuforj (revumenib) reduced the leukemia burden and improved survival in an acute myeloid leukemia cell line xenograft model harboring a KMT2A rearrangement (MLL-r) and FLT3-ITD compared to vehicle-treated, but only inhibited cell viability after prolonged treatment in culture (PMID: 35017466). | 35017466 |
PubMed Id | Reference Title | Details |
---|---|---|
(35017466) | Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c). | Full reference... |