Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Molecular Profile | KMT2A rearrange FLT3 exon 14 ins |
Therapy | Revumenib + Venetoclax |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KMT2A rearrange FLT3 exon 14 ins | acute myeloid leukemia | sensitive | Revumenib + Venetoclax | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of Revuforj (revumenib) and Venclexta (venetoclax) reduced the leukemia burden and improved survival in an acute myeloid leukemia cell line xenograft model harboring a KMT2A rearrangement and FLT3-ITD compared to either treatment alone, and demonstrated synergy in culture, resulting in decreased viability (PMID: 35017466). | 35017466 |
PubMed Id | Reference Title | Details |
---|---|---|
(35017466) | Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c). | Full reference... |