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Molecular Profile | FLT3 exon 14 ins FLT3 D839G |
Therapy | Crenolanib |
Indication/Tumor Type | hematologic cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins FLT3 D839G | hematologic cancer | sensitive | Crenolanib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed hematologic cells expressing FLT3-ITD and FLT3 D839G were sensitive to Crenolanib (CP-868596) treatment in culture (PMID: 34768286). | 34768286 |
PubMed Id | Reference Title | Details |
---|---|---|
(34768286) | Momelotinib is a highly potent inhibitor of FLT3-mutant AML. | Full reference... |