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Molecular Profile | PIK3CA mutant |
Therapy | PWT33597 |
Indication/Tumor Type | colon cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA mutant | colon cancer | sensitive | PWT33597 | Preclinical | Actionable | In a preclinical study, PWT33597 decreased signaling of mTOR and PIK3 pathways in colon cancer cells with Pik3ca mutations (Cancer Res 2011;71(8 Suppl):Abstract nr 4485). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Preclinical characterization of PWT33597, a dual inhibitor of PI3-kinase alpha and mTOR | Full reference... |