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Molecular Profile | NRAS G13R PIK3CA H1047R |
Therapy | Ganitumab + Trametinib |
Indication/Tumor Type | rhabdomyosarcoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS G13R PIK3CA H1047R | rhabdomyosarcoma | resistant | Ganitumab + Trametinib | Preclinical - Pdx | Actionable | In a preclinical study, a patient-derived xenograft (PDX) model of rhabdomyosarcoma harboring NRAS G13R and PIK3CA H1047R was resistant to the Mekinist (trametinib) and Ganitumab (AMG-479) combination treatment (PMID: 36322002). | 36322002 |
PubMed Id | Reference Title | Details |
---|---|---|
(36322002) | The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models. | Full reference... |