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Molecular Profile | PIK3CA mutant |
Therapy | A-443654 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA mutant | Advanced Solid Tumor | sensitive | A-443654 | Preclinical | Actionable | In a preclinical study, cells expressing mutant PIK3CA demonstrated increased sensitivity to A-443654 compared to cells expressing wild-type PIK3CA (PMID: 19208828). | 19208828 |
PubMed Id | Reference Title | Details |
---|---|---|
(19208828) | Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. | Full reference... |