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Molecular Profile FLT3 exon 14 ins FLT3 D835X NRAS G13C NRAS G13R
Therapy Gilteritinib
Indication/Tumor Type acute myeloid leukemia
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 D835X NRAS G13C NRAS G13R acute myeloid leukemia predicted - resistant Gilteritinib Case Reports/Case Series Actionable In a clinical study, a patient with acute myeloid leukemia harboring FLT3-ITD and a D835 mutation progressed on Xospata (gilteritinib) treatment and was found to have acquired NRAS G13C and G13R (PMID: 31088841). 31088841
PubMed Id Reference Title Details
(31088841) Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia. Full reference...