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Molecular Profile IDH2 R140Q IDH2 I319M
Therapy Enasidenib
Indication/Tumor Type leukemia
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH2 R140Q IDH2 I319M leukemia predicted - resistant Enasidenib Preclinical - Biochemical Actionable In a preclinical study, Idhifa (enasidenib) did not inhibit Idh2 activity and R-2HG production in a leukemia cell line expressing IDH2 R140Q and I319M in culture (PMID: 36222845). 36222845
PubMed Id Reference Title Details
(36222845) Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance. Full reference...