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| Molecular Profile | IDH1 R132H IDH1 H315D |
| Therapy | IDH305 |
| Indication/Tumor Type | leukemia |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| IDH1 R132H IDH1 H315D | leukemia | predicted - resistant | IDH305 | Preclinical - Biochemical | Actionable | In a preclinical study, IDH305 did not inhibit R-2HG production in a leukemia cell line expressing IDH1 R132H and H315D in culture (PMID: 36222845). | 36222845 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36222845) | Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance. | Full reference... |