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| Molecular Profile | IDH1 R132H IDH1 A410T |
| Therapy | Ivosidenib |
| Indication/Tumor Type | leukemia |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| IDH1 R132H IDH1 A410T | leukemia | predicted - sensitive | Ivosidenib | Preclinical - Biochemical | Actionable | In a preclinical study, Tibsovo (ivosidenib) inhibited enzymatic activity and R-2HG production in a leukemia cell line expressing IDH1 R132H and A410T in culture (PMID: 36222845). | 36222845 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36222845) | Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance. | Full reference... |