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| Molecular Profile | NRAS Q61K |
| Therapy | BI-1347 + Selumetinib |
| Indication/Tumor Type | neuroblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NRAS Q61K | neuroblastoma | sensitive | BI-1347 + Selumetinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of BI-1347 and Koselugo (selumetinib) resulted in reduced tumor growth and improved survival compared to Koselugo (selumetinib) alone in a neuroblastoma cell line xenograft model harboring NRAS Q61K (PMID: 36398965). | 36398965 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36398965) | Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors. | Full reference... |