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| Molecular Profile | ERBB3 D297H |
| Therapy | Lapatinib |
| Indication/Tumor Type | head and neck squamous cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ERBB3 D297H | head and neck squamous cell carcinoma | sensitive | Lapatinib | Preclinical - Cell culture | Actionable | In a preclinical study, Tykerb (lapatinib) treatment inhibited viability of a hypopharyngeal squamous cell carcinoma cell line harboring ERBB3 (HER3) D297H in culture (PMID: 33473169). | 33473169 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (33473169) | Comparative analysis of drug response and gene profiling of HER2-targeted tyrosine kinase inhibitors. | Full reference... |