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| Molecular Profile | ERBB3 M91I |
| Therapy | Lapatinib |
| Indication/Tumor Type | bladder carcinoma |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ERBB3 M91I | bladder carcinoma | resistant | Lapatinib | Preclinical - Cell culture | Actionable | In a preclinical study, a bladder carcinoma cell line harboring ERBB3 (HER3) M91I was resistant to Tykerb (lapatinib) in culture (PMID: 33473169). | 33473169 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (33473169) | Comparative analysis of drug response and gene profiling of HER2-targeted tyrosine kinase inhibitors. | Full reference... |