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| Molecular Profile | EML4 - ALK |
| Therapy | Alectinib |
| Indication/Tumor Type | duodenum adenocarcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| EML4 - ALK | duodenum adenocarcinoma | predicted - sensitive | Alectinib | Case Reports/Case Series | Actionable | In a clinical case study, Alecensa (alectinib) treatment resulted in a partial response with 57% tumor reduction after 49 days in a patient with metastatic duodenum adenocarcinoma harboring EML4-ALK, who remained on treatment and progression-free at 6 months (PMID: 36713517). | 36713517 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36713517) | Exceptional response to alectinib for duodenal carcinoma with ALK fusion: A case report and literature review. | Full reference... |