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Molecular Profile | PIK3CA E545K |
Therapy | PW12 |
Indication/Tumor Type | cervical cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA E545K | cervical cancer | sensitive | PW12 | Preclinical | Actionable | In a preclinical study, PW12 inhibited proliferation of cervical cancer cells with a PIK3CA E545K mutation (PMID: 22391131). | 22391131 |
PubMed Id | Reference Title | Details |
---|---|---|
(22391131) | High levels of p110δ PI3K expression in solid tumor cells suppress PTEN activity, generating cellular sensitivity to p110δ inhibitors through PTEN activation. | Full reference... |