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| Molecular Profile | PIK3CA E545K |
| Therapy | PW12 |
| Indication/Tumor Type | cervical cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA E545K | cervical cancer | sensitive | PW12 | Preclinical | Actionable | In a preclinical study, PW12 inhibited proliferation of cervical cancer cells with a PIK3CA E545K mutation (PMID: 22391131). | 22391131 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (22391131) | High levels of p110δ PI3K expression in solid tumor cells suppress PTEN activity, generating cellular sensitivity to p110δ inhibitors through PTEN activation. | Full reference... |