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Molecular Profile | TET2 del |
Therapy | Eltanexor |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TET2 del | acute myeloid leukemia | sensitive | Eltanexor | Preclinical - Cell culture | Actionable | In a preclinical study, Eltanexor (KPT-8602) induced apoptosis in TET2-knockout acute myeloid leukemia cell lines, resulting in decreased cell viability in culture (PMID: 36746437). | 36746437 |
PubMed Id | Reference Title | Details |
---|---|---|
(36746437) | Synthetic lethal targeting of TET2-mutant haematopoietic stem and progenitor cells by XPO1 inhibitors. | Full reference... |