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| Molecular Profile | POLE V411L |
| Therapy | unspecified PD-1 antibody |
| Indication/Tumor Type | melanoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| POLE V411L | melanoma | sensitive | unspecified PD-1 antibody | Preclinical | Actionable | In a preclinical study, a murine anti-PD1 antibody inhibited tumor growth in a syngeneic mouse model of melanoma expressing POLE V411L (PMID: 35817971). | 35817971 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (35817971) | Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity. | Full reference... |