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| Molecular Profile | ALK F1174L TP53 wild-type |
| Therapy | Idasanutlin + TAE684 |
| Indication/Tumor Type | neuroblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ALK F1174L TP53 wild-type | neuroblastoma | sensitive | Idasanutlin + TAE684 | Case Reports/Case Series | Actionable | In a preclinical study, TAE684 and Idasanutlin (RG7388) synergistically inhibited growth and induced apoptosis in a TP53 wild-type neuroblastoma cell line harboring ALK F1174L in culture (PMID: 36602782). | 36602782 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36602782) | Combination Therapies Targeting ALK-aberrant Neuroblastoma in Preclinical Models. | Full reference... |