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Molecular Profile | ALK R1275Q TP53 wild-type |
Therapy | Idasanutlin + TAE684 |
Indication/Tumor Type | neuroblastoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ALK R1275Q TP53 wild-type | neuroblastoma | sensitive | Idasanutlin + TAE684 | Preclinical - Cell culture | Actionable | In a preclinical study, the combination of TAE684 and Idasanutlin (RG7388) inhibited growth of a TP53 wild-type neuroblastoma cell line harboring ALK R1275Q in culture (PMID: 36602782). | 36602782 |
PubMed Id | Reference Title | Details |
---|---|---|
(36602782) | Combination Therapies Targeting ALK-aberrant Neuroblastoma in Preclinical Models. | Full reference... |