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Molecular Profile | ALK amp |
Therapy | Cyclophosphamide + Doxorubicin + Lorlatinib + Vincristine Sulfate |
Indication/Tumor Type | neuroblastoma |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ALK amp | neuroblastoma | no benefit | Cyclophosphamide + Doxorubicin + Lorlatinib + Vincristine Sulfate | Preclinical - Pdx | Actionable | In a preclinical study, addition of Cytoxan (cyclophosphamide), Adriamycin (doxorubicin), and Oncovin (vincristine) to Lorbrena (lorlatinib) did not improve tumor growth inhibition in a patient-derived xenograft (PDX) model of neuroblastoma with ALK amplification and overexpression (PMID: 36602782). | 36602782 |
PubMed Id | Reference Title | Details |
---|---|---|
(36602782) | Combination Therapies Targeting ALK-aberrant Neuroblastoma in Preclinical Models. | Full reference... |