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| Molecular Profile | BTK C481S |
| Therapy | Vecabrutinib |
| Indication/Tumor Type | chronic lymphocytic leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BTK C481S | chronic lymphocytic leukemia | sensitive | Vecabrutinib | Preclinical - Cell culture | Actionable | In a preclinical study, Vecabrutinib (SNS-062) inhibited viability of a chronic lymphocytic leukemia cell line harboring BTK C481S (PMID: 34662393). | 34662393 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34662393) | Evaluation of vecabrutinib as a model for noncovalent BTK/ITK inhibition for treatment of chronic lymphocytic leukemia. | Full reference... |