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| Molecular Profile | BTK E41K |
| Therapy | Vecabrutinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BTK E41K | Advanced Solid Tumor | predicted - sensitive | Vecabrutinib | Preclinical - Biochemical | Actionable | In a preclinical study, Vecabrutinib (SNS-062) inhibited Plcg2 activity in cells expressing BTK E41K in an in vitro assay (PMID: 34662393). | 34662393 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34662393) | Evaluation of vecabrutinib as a model for noncovalent BTK/ITK inhibition for treatment of chronic lymphocytic leukemia. | Full reference... |