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| Molecular Profile | ERBB4 G741R |
| Therapy | Afatinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ERBB4 G741R | Advanced Solid Tumor | sensitive | Afatinib | Preclinical - Cell culture | Actionable | In a preclinical study, Gilotrif (afatinib) inhibited growth of a transformed cell line expressing ERBB4 G741R in culture (PMID: 36860695). | 36860695 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36860695) | An Unbiased Functional Genetics Screen Identifies Rare Activating ERBB4 Mutations. | Full reference... |