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Molecular Profile | PIK3CA H1047R |
Therapy | Alpelisib + Everolimus |
Indication/Tumor Type | estrogen-receptor positive breast cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA H1047R | estrogen-receptor positive breast cancer | predicted - sensitive | Alpelisib + Everolimus | Preclinical - Patient cell culture | Actionable | In a preclinical study, combination treatment with Piqray (albelisib) and Afinitor (everolimus) synergistically inhibited cell viability of patient-derived ESR1 (ER)-positive breast cancer cells harboring PIK3CA H1047R and ESR1 (ER alpha) Y537S in culture (PMID: 36900375). | 36900375 |
PubMed Id | Reference Title | Details |
---|---|---|
(36900375) | Discovering Synergistic Compounds with BYL-719 in PI3K Overactivated Basal-like PDXs. | Full reference... |