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Molecular Profile PIK3CA H1047R
Therapy Afatinib + Alpelisib
Indication/Tumor Type estrogen-receptor positive breast cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA H1047R estrogen-receptor positive breast cancer predicted - sensitive Afatinib + Alpelisib Preclinical - Patient cell culture Actionable In a preclinical study, combination treatment with Piqray (albelisib) and Gilotrif (afatinib) synergistically inhibited cell viability of patient-derived ESR1 (ER)-positive breast cancer cells harboring PIK3CA H1047R and ESR1 (ER alpha) Y537S in culture (PMID: 36900375). 36900375
PubMed Id Reference Title Details
(36900375) Discovering Synergistic Compounds with BYL-719 in PI3K Overactivated Basal-like PDXs. Full reference...